PDBsum entry 2lbm

Metal binding protein/structural protein

PDB id

2lbm

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Contents

			Protein chains

					142 a.a.


					15 a.a.

			Metals

					_ZN ×3

PDB id:

2lbm

Links
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Name:

Metal binding protein/structural protein

Title:

Solution structure of the add domain of atrx complexed with histone tail h3 1-15 k9me3

Structure:

Transcriptional regulator atrx. Chain: a. Fragment: unp residues 159-296. Synonym: atp-dependent helicase atrx, x-linked helicase ii, x-linked nuclear protein, xnp, znf-hx. Engineered: yes. Histone tail h3 k9me3. Chain: c. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: atrx, rad54l, xh2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

NMR struc:

25 models

Authors:

S.Eustermann,J.Yang,D.Neuhaus

Key ref:

S.Eustermann et al. (2011). Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nat Struct Biol, 18, 777-782. PubMed id: 21666677

Date:

08-Apr-11

Release date:

29-Jun-11

PROCHECK

	Headers

	References

Protein chain

P46100 (ATRX_HUMAN) - Transcriptional regulator ATRX from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					2492 a.a. 142 a.a.*

Protein chain

P68431 (H31_HUMAN) - Histone H3.1 from Homo sapiens

Seq: Struc:					136 a.a. 15 a.a.*

Key:

PfamA domain

Secondary structure

* PDB and UniProt seqs differ at 6 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

Chain A: E.C.3.6.4.12 - Dna helicase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

ATP + H2O = ADP + phosphate + H⁺

ATP	+	H2O	=	ADP	+	phosphate	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	Nat Struct Biol 18:777-782 (2011)
PubMed id: 21666677

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
S.Eustermann, J.C.Yang, M.J.Law, R.Amos, L.M.Chapman, C.Jelinska, D.Garrick, D.Clynes, R.J.Gibbons, D.Rhodes, D.R.Higgs, D.Neuhaus.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23211769

C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.

Nat Struct Mol Biol, 19, 1218-1227.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.