PDBsum entry 2law

Signaling protein/transcription

PDB id: 2law

Contents

Protein chains

34 a.a.

12 a.a.

PDB id:

2law

Name:

Signaling protein/transcription

Title:

Structure of the second ww domain from human yap in complex with a human smad1 derived peptide

Structure:

Yorkie homolog. Chain: a. Fragment: second ww domain, residues 230-263. Synonym: 65 kda yes-associated protein, yap65. Engineered: yes. Mothers against decapentaplegic homolog 1. Chain: b. Fragment: residues 222-233. Synonym: mad homolog 1, mothers against dpp homolog 1, jv4-1, mad-

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: yap1, yap65. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

NMR struc:

20 models

Authors:

M.J.Macias,E.Aragon,N.Goerner,A.Zaromytidou,Q.Xi,A.Escobedo, J.Massague

Key ref:

E.Aragón et al. (2011). A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev, 25, 1275-1288. PubMed id: 21685363

Date:

22-Mar-11 Release date: 06-Jul-11

Protein chain

P46937  (YAP1_HUMAN) -  Transcriptional coactivator YAP1 from Homo sapiens

Seq: 504 a.a.

Struc: 34 a.a.

Protein chain

Q15797  (SMAD1_HUMAN) -  Mothers against decapentaplegic homolog 1 from Homo sapiens

Seq: 465 a.a.

Struc: 12 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?

Genes Dev 25:1275-1288 (2011)

PubMed id: 21685363

A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

E.Aragón, N.Goerner, A.I.Zaromytidou, Q.Xi, A.Escobedo, J.Massagué, M.J.Macias.

ABSTRACT

No abstract given.