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PDBsum entry 2laj
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Ligase/transcription regulator
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PDB id
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2laj
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PDB id:
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Ligase/transcription regulator
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Title:
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Third ww domain of human nedd4l in complex with doubly phosphorylated human smad3 derived peptide
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Structure:
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E3 ubiquitin-protein ligase nedd4-like. Chain: a. Fragment: ww 3 domain residues 496-535. Synonym: nedd4.2, nedd4-2. Engineered: yes. Mothers against decapentaplegic homolog 3. Chain: b. Fragment: sequence database residues 202-211. Synonym: mad homolog 3, mad3, mothers against dpp homolog 3, hmad-3,
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: nedd4l, kiaa0439, nedl3. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606
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NMR struc:
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15 models
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Authors:
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M.J.Macias,E.Aragon,N.Goerner,A.Zaromytidou,Q.Xi,A.Escobedo, J.Massague
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Key ref:
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E.Aragón
et al.
(2011).
A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev,
25,
1275-1288.
PubMed id:
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Date:
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16-Mar-11
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Release date:
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06-Jul-11
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PROCHECK
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Headers
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References
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Q96PU5
(NED4L_HUMAN) -
E3 ubiquitin-protein ligase NEDD4-like from Homo sapiens
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Seq:
Struc:
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975 a.a.
40 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class 1:
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E.C.2.3.2.26
- HECT-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Enzyme class 2:
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E.C.2.3.2.36
- RING-type E3 ubiquitin transferase (cysteine targeting).
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Reaction:
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[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Genes Dev
25:1275-1288
(2011)
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PubMed id:
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A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
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E.Aragón,
N.Goerner,
A.I.Zaromytidou,
Q.Xi,
A.Escobedo,
J.Massagué,
M.J.Macias.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.Massagué
(2012).
TGFβ signalling in context.
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Nat Rev Mol Cell Biol,
13,
616-630.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
