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UniProt functional annotation for P25801 | ||
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| UniProt code: P25801. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. {ECO:0000269|PubMed:9391090}. |
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| Subunit: | |
Interacts with BEX2 and KDM5A (By similarity). Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix- loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL. {ECO:0000250, ECO:0000269|PubMed:12727888, ECO:0000269|PubMed:9001422, ECO:0000269|PubMed:9391090}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:9391090}. |
| Tissue specificity: | |
Expressed in early mouse development in central nervous system, lung, kidney, liver and spleen but only very low levels occur in thymus. {ECO:0000269|PubMed:2034676}. |
| Domain: | |
The second LIM zinc-binding domain interacts with KDM5A. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.