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PDBsum entry 2l6z
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protein metals Protein-protein interface(s) links
Transcription regulation/oncoprotein PDB id
2l6z

 

 

 

 

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Contents
Protein chains
39 a.a.
36 a.a.
96 a.a.
Metals
_ZN ×4
PDB id:
2l6z
Name: Transcription regulation/oncoprotein
Title: Haddock model of gata1nf:lmo2lim2-ldb1lid with fog
Structure: Erythroid transcription factor. Chain: a. Fragment: gata-type 1 domain, residues 200-238. Synonym: eryf1, gata-binding factor 1, gata-1, gf-1, nf-e1 DNA- binding protein. Engineered: yes. Zinc finger protein ush. Chain: b. Fragment: unp residues 202-235.
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Drosophila melanogaster. Fruit fly. Organism_taxid: 7227.
NMR struc: 10 models
Authors: L.Wilkinson-White,R.Gamsjaeger,S.Dastmalchi,B.Wienert,P.H.Stokes, M.Crossley,J.P.Mackay,J.M.Matthews
Key ref: L.Wilkinson-White et al. (2011). Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proc Natl Acad Sci U S A, 108, 14443-14448. PubMed id: 21844373
Date:
01-Dec-10     Release date:   31-Aug-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P17679  (GATA1_MOUSE) -  Erythroid transcription factor from Mus musculus
Seq:
Struc: 		413 a.a.
39 a.a.
Protein chain
Pfam   ArchSchema ?
Q9VPQ6  (USH_DROME) -  Zinc finger protein ush from Drosophila melanogaster
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1191 a.a.
36 a.a.*
Protein chain
Pfam   ArchSchema ?
P25801  (RBTN2_MOUSE) -  Rhombotin-2 from Mus musculus
Seq:
Struc: 		158 a.a.
96 a.a.*
Protein chain
Pfam   ArchSchema ?
P70662  (LDB1_MOUSE) -  LIM domain-binding protein 1 from Mus musculus
Seq:
Struc: 		411 a.a.
96 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 84 residue positions (black crosses)

 

 
Proc Natl Acad Sci U S A 108:14443-14448 (2011)
PubMed id: 21844373  
 
 
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1.
L.Wilkinson-White, R.Gamsjaeger, S.Dastmalchi, B.Wienert, P.H.Stokes, M.Crossley, J.P.Mackay, J.M.Matthews.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23303138 J.M.Matthews, K.Lester, S.Joseph, and D.J.Curtis (2012).
LIM-domain-only proteins in cancer.
  Nat Rev Cancer, 13, 111-122.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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