PDBsum entry 2l5y

Signaling protein

PDB id

2l5y

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Contents

			Protein chain

					150 a.a. *

			Metals

					_CA

* Residue conservation analysis

PDB id:

2l5y

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

Signaling protein

Title:

Nmr structure of calcium-loaded stim2 ef-sam.

Structure:

Stromal interaction molecule 2. Chain: a. Fragment: unp residues 62-205. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa1482, stim2. Expressed in: escherichia coli. Expression_system_taxid: 562.

NMR struc:

20 models

Authors:

L.Zheng,P.B.Stathopulos,M.Ikura

Key ref:

L.Zheng et al. (2011). Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry. Proc Natl Acad Sci U S A, 108, 1337-1342. PubMed id: 21217057

Date:

09-Nov-10

Release date:

19-Jan-11

PROCHECK

	Headers

	References

Protein chain

Q9P246 (STIM2_HUMAN) - Stromal interaction molecule 2 from Homo sapiens

Seq: Struc:

Seq: Struc:					746 a.a. 150 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 5 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Proc Natl Acad Sci U S A 108:1337-1342 (2011)
PubMed id: 21217057

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.
L.Zheng, P.B.Stathopulos, R.Schindl, G.Y.Li, C.Romanin, M.Ikura.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22914293

J.Soboloff, B.S.Rothberg, M.Madesh, and D.L.Gill (2012).
STIM proteins: dynamic calcium signal transducers.

Nat Rev Mol Cell Biol, 13, 549-565.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.