PDBsum entry 2l5u

Metal binding protein

PDB id

2l5u

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Contents

			Protein chain

					61 a.a. *

			Metals

					_ZN ×2

* Residue conservation analysis

PDB id:

2l5u

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

Metal binding protein

Title:

Structure of the first phd finger (phd1) from chd4 (mi2b)

Structure:

Chromodomain-helicase-DNA-binding protein 4. Chain: a. Fragment: phd1 domain, unp residues 365-420. Synonym: chd-4, atp-dependent helicase chd4, mi-2 autoantigen 218 kda protein, mi2-beta. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: chd4. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: pgex-6pe is an edited version of pgex-2t which contains an hrv3c protease cleavage site.

NMR struc:

20 models

Authors:

R.E.Mansfield,A.H.Kwan,J.P.Mackay

Key ref:

R.E.Mansfield et al. (2011). Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J Biol Chem, 286, 11779-11791. PubMed id: 21278251

Date:

08-Nov-10

Release date:

19-Jan-11

PROCHECK

	Headers

	References

Protein chain

Q14839 (CHD4_HUMAN) - Chromodomain-helicase-DNA-binding protein 4 from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1912 a.a. 61 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 5 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.3.6.4.12 - Dna helicase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

ATP + H2O = ADP + phosphate + H⁺

ATP	+	H2O	=	ADP	+	phosphate	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	J Biol Chem 286:11779-11791 (2011)
PubMed id: 21278251

Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9.
R.E.Mansfield, C.A.Musselman, A.H.Kwan, S.S.Oliver, A.L.Garske, F.Davrazou, J.M.Denu, T.G.Kutateladze, J.P.Mackay.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23211769

C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.

Nat Struct Mol Biol, 19, 1218-1227.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.