|
|
||
|
|
|
|
|
UniProt functional annotation for Q05876 | ||
|
|
|
|
|
|
||
| UniProt code: Q05876. |
|
||
| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
|
||
|
||
| Function: | |
Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. {ECO:0000269|PubMed:7496631}. |
|
||
| Catalytic activity: | |
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| Activity regulation: | |
Inhibited by phosphorylation of Tyr-528 by leukocyte common antigen and activated by dephosphorylation of this site. {ECO:0000250}. |
| Subunit: | |
Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. |
| Tissue specificity: | |
Thymus and spleen. {ECO:0000269|PubMed:8455940}. |
| Similarity: | |
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}. |
Annotations taken from UniProtKB at the EBI.