PDBsum entry 2l1r

Metal binding protein

PDB id: 2l1r

Contents

Protein chains

89 a.a. *

20 a.a. *

Ligands

SXK

Metals

_CA

* Residue conservation analysis

PDB id:

2l1r

Name:

Metal binding protein

Title:

The structure of the calcium-sensitizer, dfbp-o, in complex with the n-domain of troponin c and the switch region of troponin i

Structure:

Troponin c. Chain: a. Fragment: n-terminal domain. Synonym: tn-c. Engineered: yes. Troponin i. Chain: b. Fragment: switch region. Synonym: cardiac troponin i.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tnnc1, tnnc. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

NMR struc:

20 models

Authors:

I.M.Robertson,Y.Sun,M.X.Li,B.D.Sykes

Key ref:

I.M.Robertson et al. (2010). A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex. J Mol Cell Cardiol, 49, 1031-1041. PubMed id: 20801130

Date:

03-Aug-10 Release date: 18-Aug-10

Protein chain

P63316  (TNNC1_HUMAN) -  Troponin C, slow skeletal and cardiac muscles from Homo sapiens

Seq: 161 a.a.

Struc: 89 a.a.

Protein chain

P19429  (TNNI3_HUMAN) -  Troponin I, cardiac muscle from Homo sapiens

Seq: 210 a.a.

Struc: 20 a.a.

J Mol Cell Cardiol 49:1031-1041 (2010)

PubMed id: 20801130

A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex.

I.M.Robertson, Y.B.Sun, M.X.Li, B.D.Sykes.

ABSTRACT

No abstract given.