UniProt functional annotation for Q92783



	UniProt functional annotation for Q92783

UniProt code: Q92783.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:11687594, PubMed:9407053, PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15 (PubMed:12551915). Found in a complex with HGS and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with STAMBP/AMSH (PubMed:10383417). Interacts with PDGFRB (PubMed:20494825). Interacts with LITAF; the interaction is direct (PubMed:23166352). Identified in a complex with HGS and LITAF (PubMed:23166352). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11687594, ECO:0000269|PubMed:12551915, ECO:0000269|PubMed:19278655, ECO:0000269|PubMed:20150893, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:9407053}.

Subcellular location: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}.

Tissue specificity: Ubiquitously expressed. {ECO:0000269|PubMed:8780729}.

Domain: The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos. {ECO:0000269|PubMed:20150893}.

Ptm: Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. {ECO:0000269|PubMed:11687594, ECO:0000269|PubMed:20494825}.

Ptm: Ubiquitinated by ITCH. {ECO:0000269|PubMed:24790097}.

Similarity: Belongs to the STAM family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.


Subunit:		Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS (PubMed:11687594, PubMed:9407053, PubMed:19278655). Probably part of a complex at least composed of HSG, STAM and EPS15 (PubMed:12551915). Found in a complex with HGS and E3 ligase ITCH and DTX3L (PubMed:24790097). Interacts with E3 ligase DTX3L; the interaction brings together STAM and HSG, promotes their recruitment to early endosomes and decreases STAM and HGS ubiquitination by ITCH (PubMed:24790097). Interacts with STAMBP/AMSH (PubMed:10383417). Interacts with PDGFRB (PubMed:20494825). Interacts with LITAF; the interaction is direct (PubMed:23166352). Identified in a complex with HGS and LITAF (PubMed:23166352). {ECO:0000269\|PubMed:10383417, ECO:0000269\|PubMed:11687594, ECO:0000269\|PubMed:12551915, ECO:0000269\|PubMed:19278655, ECO:0000269\|PubMed:20150893, ECO:0000269\|PubMed:20494825, ECO:0000269\|PubMed:23166352, ECO:0000269\|PubMed:24790097, ECO:0000269\|PubMed:9407053}.
Subcellular location:		Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000269\|PubMed:23166352, ECO:0000269\|PubMed:24790097}; Peripheral membrane protein {ECO:0000305\|PubMed:23166352, ECO:0000305\|PubMed:24790097}; Cytoplasmic side {ECO:0000305\|PubMed:23166352, ECO:0000305\|PubMed:24790097}.
Tissue specificity:		Ubiquitously expressed. {ECO:0000269\|PubMed:8780729}.
Domain:		The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos. {ECO:0000269\|PubMed:20150893}.
Ptm:		Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. {ECO:0000269\|PubMed:11687594, ECO:0000269\|PubMed:20494825}.
Ptm:		Ubiquitinated by ITCH. {ECO:0000269\|PubMed:24790097}.
Similarity:		Belongs to the STAM family. {ECO:0000305}.