UniProt functional annotation for Q9YDF8

UniProt code: Q9YDF8.

Organism:		Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1).
Taxonomy:		Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
Function:		Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:12629550}.
Subcellular location:		Cell membrane; Multi-pass membrane protein.
Domain:		Contains a central ion-conduction pore surrounded by four voltage sensors which form the voltage-sensor paddles that move in response to membrane voltage changes through the fluid membrane interior, each voltage-sensor carrying their four positive charges across the membrane. It is thought that the S4 arginine residues move through the membrane's electric field to open the pore.
Similarity:		Belongs to the potassium channel family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.