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UniProt functional annotation for P62774 | ||
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| UniProt code: P62774. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin- capping protein complex formed by the CAPZA1 and CAPZB heterodimer. {ECO:0000250, ECO:0000269|PubMed:20538588}. |
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| Subunit: | |
Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB. {ECO:0000250, ECO:0000269|PubMed:20538588}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. |
| Similarity: | |
Belongs to the myotrophin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.