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PDBsum entry 2kxc
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protein Protein-protein interface(s) links
Protein binding PDB id
2kxc

 

 

 

 

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Contents
Protein chains
67 a.a. *
17 a.a. *
* Residue conservation analysis
PDB id:
2kxc
Name: Protein binding
Title: 1h, 13c, and 15n chemical shift assignments for irtks-sh3 and espfu- r47 complex
Structure: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1. Chain: a. Fragment: irtks-sh3 domain, unp residues 339-402. Synonym: bai1-associated protein 2-like protein 1, insulin receptor tyrosine kinase substrate. Engineered: yes. Espf-like protein. Chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: baiap2l1, irtks. Expressed in: escherichia coli. Expression_system_taxid: 562. Escherichia coli. Organism_taxid: 83334. Strain: o157:h7.
NMR struc: 20 models
Authors: O.Aitio,M.Hellman,A.Kazlauskas,D.F.Vingadassalom,J.M.Leong,K.Saksela, P.Permi
Key ref: O.Aitio et al. (2010). Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Proc Natl Acad Sci U S A, 107, 21743-21748. PubMed id: 21098279
Date:
30-Apr-10     Release date:   17-Nov-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9UHR4  (BI2L1_HUMAN) -  BAR/IMD domain-containing adapter protein 2-like 1 from Homo sapiens
Seq:
Struc: 		511 a.a.
67 a.a.*
Protein chain
Pfam   ArchSchema ?
P0DJ89  (ESFU3_ECO57) -  Secreted effector protein EspF(U) from Escherichia coli O157:H7
Seq:
Struc: 		337 a.a.
17 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 

 
Proc Natl Acad Sci U S A 107:21743-21748 (2010)
PubMed id: 21098279  
 
 
Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.
O.Aitio, M.Hellman, A.Kazlauskas, D.F.Vingadassalom, J.M.Leong, K.Saksela, P.Permi.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21857683 H.X.Deng, W.Chen, S.T.Hong, K.M.Boycott, G.H.Gorrie, N.Siddique, Y.Yang, F.Fecto, Y.Shi, H.Zhai, H.Jiang, M.Hirano, E.Rampersaud, G.H.Jansen, S.Donkervoort, E.H.Bigio, B.R.Brooks, K.Ajroud, R.L.Sufit, J.L.Haines, E.Mugnaini, M.A.Pericak-Vance, and T.Siddique (2011).
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
  Nature, 477, 211-215.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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