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PDBsum entry 2kwv
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protein Protein-protein interface(s) links
Protein binding/signaling protein PDB id
2kwv

 

 

 

 

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Contents
Protein chains
36 a.a.
76 a.a. *
* Residue conservation analysis
PDB id:
2kwv
Name: Protein binding/signaling protein
Title: Solution structure of ubm1 of murine polymerase iota in complex with ubiquitin
Structure: DNA polymerase iota. Chain: a. Fragment: c-terminal ubiquitin-binding motif (unp residues 487-532). Synonym: rad30 homolog b. Engineered: yes. Ubiquitin. Chain: b. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: poli, rad30b. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
NMR struc: 20 models
Authors: D.Burschowsky,F.Rudolf,G.Rabut,T.Herrmann,M.Peter,G.Wider
Key ref: D.Burschowsky et al. (2011). Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin. J Biol Chem, 286, 1364-1373. PubMed id: 20929865
Date:
20-Apr-10     Release date:   06-Oct-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q6R3M4  (POLI_MOUSE) -  DNA polymerase iota from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		717 a.a.
36 a.a.*
Protein chain
Pfam   ArchSchema ?
P0CG47  (UBB_HUMAN) -  Polyubiquitin-B from Homo sapiens
Seq:
Struc: 		229 a.a.
76 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class 2: Chain A: E.C.2.7.7.7  - DNA-directed Dna polymerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
DNA(n)
 + 2'-deoxyribonucleoside 5'-triphosphate
 = DNA(n+1)
 + diphosphate
   Enzyme class 3: Chain B: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Added reference    
 
 
J Biol Chem 286:1364-1373 (2011)
PubMed id: 20929865  
 
 
Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin.
D.Burschowsky, F.Rudolf, G.Rabut, T.Herrmann, M.Peter, P.Matthias, G.Wider.
 
  ABSTRACT  
 
No abstract given.

 

 

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