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UniProt functional annotation for Q9JKD9 | ||
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| UniProt code: Q9JKD9. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor (By similarity). Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T- cells. {ECO:0000250, ECO:0000269|PubMed:11279021}. |
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| Subunit: | |
Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16 (By similarity). Interacts with GATA3. {ECO:0000250, ECO:0000269|PubMed:10755619}. |
| Subcellular location: | |
Nucleus. Note=Located in nuclear speckles. {ECO:0000250}. |
| Tissue specificity: | |
Isoform 1 is testis-specific and is not expressed in lymphoid organs such as thymus or spleen. Isoform 2 is expressed in both B- and T-lymphoid cells. {ECO:0000269|PubMed:10755619}. |
| Domain: | |
The C-terminal zinc finger domain functions as a transcriptional transactivator. |
| Domain: | |
The BTB (POZ) domain possesses repressor activity. |
| Similarity: | |
Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.