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UniProt functional annotation for O14924 | ||
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| UniProt code: O14924. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. {ECO:0000250|UniProtKB:O08774}. |
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| Function: | |
[Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. {ECO:0000269|PubMed:12024043}. |
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| Subunit: | |
Interacts with GNAI1 (PubMed:18434541). Interacts with GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity). {ECO:0000250|UniProtKB:O08774, ECO:0000269|PubMed:18434541}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:10869340}. Cytoplasm {ECO:0000250|UniProtKB:O08774}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08774}. Cell junction, synapse {ECO:0000250|UniProtKB:O08774}. |
| Subcellular location: | |
[Isoform 5]: Nucleus matrix {ECO:0000269|PubMed:12024043}. Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. {ECO:0000269|PubMed:12024043}. |
| Tissue specificity: | |
Isoform 3 is brain specific. |
| Domain: | |
The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.