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PDBsum entry 2kre

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protein links
Protein binding PDB id
2kre
Jmol PyMol
Contents
Protein chain
100 a.a. *
* Residue conservation analysis
PDB id:
2kre
Name: Protein binding
Title: Solution structure of e4b/ufd2a u-box domain
Structure: Ubiquitin conjugation factor e4 b. Chain: a. Fragment: unp residues 1208-1302. Synonym: ubiquitin fusion degradation protein 2, homozygous in neuroblastoma 1. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hdnb1, kiaa0684, ube4b, ufd2. Expressed in: escherichia coli. Expression_system_taxid: 562.
NMR struc: 20 models
Authors: Y.Nomine,E.Wasielewski,M.Botuyan,G.Mer
Key ref: R.C.Benirschke et al. (2010). Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4. Structure, 18, 955-965. PubMed id: 20696396
Date:
16-Dec-09     Release date:   29-Dec-09    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
O95155  (UBE4B_HUMAN) -  Ubiquitin conjugation factor E4 B
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1302 a.a.
100 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.3.2.27  - RING-type E3 ubiquitin transferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein ubiquitination   1 term 
  Biochemical function     ubiquitin-protein ligase activity     1 term  

 

 
Structure 18:955-965 (2010)
PubMed id: 20696396  
 
 
Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.
R.C.Benirschke, J.R.Thompson, Y.Nominé, E.Wasielewski, N.Juranić, S.Macura, S.Hatakeyama, K.I.Nakayama, M.V.Botuyan, G.Mer.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20696387 A.Pastore (2010).
Further insights into the ubiquitin pathway: understanding the scarlet letter code.
  Structure, 18, 891-892.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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