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PDBsum entry 2kqh
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References listed in PDB file
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Key reference
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Title
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A g-Rich sequence within the c-Kit oncogene promoter forms a parallel g-Quadruplex having asymmetric g-Tetrad dynamics.
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Authors
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S.T.Hsu,
P.Varnai,
A.Bugaut,
A.P.Reszka,
S.Neidle,
S.Balasubramanian.
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Ref.
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J Am Chem Soc, 2009,
131,
13399-13409.
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PubMed id
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Abstract
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Guanine-rich DNA sequences with the ability to form quadruplex structures are
enriched in the promoter regions of protein-coding genes, particularly those of
proto-oncogenes. G-quadruplexes are structurally polymorphic and their folding
topologies can depend on the sample conditions. We report here on a structural
study using solution state NMR spectroscopy of a second G-quadruplex-forming
motif (c-kit2) that has been recently identified in the promoter region of the
c-kit oncogene. In the presence of potassium ions, c-kit2 exists as an ensemble
of structures that share the same parallel-stranded propeller-type
conformations. Subtle differences in structural dynamics have been identified
using hydrogen-deuterium exchange experiments by NMR spectroscopy, suggesting
the coexistence of at least two structurally similar but dynamically distinct
substates, which undergo slow interconversion on the NMR timescale.
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Secondary reference #1
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Title
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A conserved quadruplex motif located in a transcription activation site of the human c-Kit oncogene.
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Authors
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H.Fernando,
A.P.Reszka,
J.Huppert,
S.Ladame,
S.Rankin,
A.R.Venkitaraman,
S.Neidle,
S.Balasubramanian.
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Ref.
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Biochemistry, 2006,
45,
7854-7860.
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PubMed id
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Headers
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