PDBsum entry 2kqf

Signaling protein/peptide binding protei

PDB id: 2kqf

Contents

Protein chains

96 a.a. *

13 a.a. *

* Residue conservation analysis

PDB id:

2kqf

Name:

Signaling protein/peptide binding protei

Title:

Solution structure of mast205-pdz complexed with thE C-terminus of a rabies virus g protein

Structure:

Microtubule-associated serine/threonine-protein kinase 2. Chain: a. Fragment: pdz domain. Engineered: yes. C-terminal motif from glycoprotein. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mast205. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide

NMR struc:

10 models

Authors:

E.Terrien,N.Wolff,F.Cordier,C.Simenel,A.Bernard,M.Lafon,M.Delepierre

Key ref:

E.Terrien et al. 1h, 13c and 15n resonance assignments of the pdz of microtubule-Associated serine/threonine kinase 205 (m in complex with the c-Terminal motif from the rabies glycoprotein. To be published, .

Date:

04-Nov-09 Release date: 10-Nov-10

Protein chain

Q6P0Q8  (MAST2_HUMAN) -  Microtubule-associated serine/threonine-protein kinase 2 from Homo sapiens

Seq: 1798 a.a.

Struc: 96 a.a.*

Protein chain

Q8JJY9  (Q8JJY9_9RHAB) -  Glycoprotein from Lyssavirus rabies

Seq: 524 a.a.

Struc: 13 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: Chain A: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
• Enzyme class 3: Chain B: E.C.?

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site