PDBsum entry 2kpl

Protein binding/oncoprotein

PDB id: 2kpl

Contents

Protein chains

129 a.a. *

11 a.a. *

* Residue conservation analysis

PDB id:

2kpl

Name:

Protein binding/oncoprotein

Title:

Magi-1 pdz1 / e6ct

Structure:

Membrane-associated guanylate kinase, ww and pdz domain- containing protein 1. Chain: a. Fragment: unp residues 455-580. Synonym: bai1-associated protein 1, bap-1, membrane-associated guanylate kinase inverted 1, magi-1, atrophin-1-interacting protein 3, aip3, ww domain-containing protein 3, wwp3, trinucleotide repeat- containing gene 19 protein. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: baiap1, bap1, magi1, tnrc19. Expressed in: escherichia coli. Expression_system_taxid: 562. Human papillomavirus type 16. Organism_taxid: 333760. Gene: e6.

NMR struc:

20 models

Authors:

S.Charbonnier,Y.Nomine,J.Ramirez,K.Luck,R.H.Stote,G.Trave,B.Kieffer, R.A.Atkinson

Key ref:

S.Charbonnier et al. (2011). The structural and dynamic response of MAGI-1 PDZ1 with noncanonical domain boundaries to the binding of human papillomavirus E6. J Mol Biol, 406, 745-763. PubMed id: 21238461

Date:

16-Oct-09 Release date: 27-Oct-10

Protein chain

Q96QZ7  (MAGI1_HUMAN) -  Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 from Homo sapiens

Seq: 1491 a.a.

Struc: 129 a.a.*

Protein chain

P03126  (VE6_HPV16) -  Protein E6 from Human papillomavirus type 16

Seq: 158 a.a.

Struc: 11 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.?

J Mol Biol 406:745-763 (2011)

PubMed id: 21238461

The structural and dynamic response of MAGI-1 PDZ1 with noncanonical domain boundaries to the binding of human papillomavirus E6.

S.Charbonnier, Y.Nominé, J.Ramírez, K.Luck, A.Chapelle, R.H.Stote, G.Travé, B.Kieffer, R.A.Atkinson.

ABSTRACT

No abstract given.