PDBsum entry 2klz

Hydrolase

PDB id: 2klz

Contents

Protein chain

46 a.a. *

* Residue conservation analysis

PDB id:

2klz

Name:

Hydrolase

Title:

Solution structure of the tandem uim domain of ataxin-3 complexed with ubiquitin

Structure:

Ataxin-3. Chain: a. Fragment: uim1 and uim 2 domain, unp residues 222-263. Synonym: machado-joseph disease protein 1, spinocerebellar ataxia type 3 protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

NMR struc:

10 models

Authors:

C.Zhou,A.Song,D.Lin,H.Hu

Key ref:

A.Song et al. Solution structure of the tandem uim domain of ataxin complexed with ubiquitin. To be published, .

Date:

12-Jul-09 Release date: 28-Jul-10

Protein chain

P54252  (ATX3_HUMAN) -  Ataxin-3 from Homo sapiens

Seq: 361 a.a.

Struc: 46 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.19.12 - ubiquitinyl hydrolase 1.
• Reaction: Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).