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UniProt functional annotation for Q99856 | ||
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| UniProt code: Q99856. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269|PubMed:11812999, ECO:0000269|PubMed:12692263}. |
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| Subunit: | |
Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK. {ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17400556, ECO:0000269|PubMed:9780002}. |
| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000269|PubMed:17400556}. Cytoplasm {ECO:0000269|PubMed:17400556}. Note=Shuttles between nucleus and cytoplasm. |
| Tissue specificity: | |
Widely expressed, with highest expression in skeletal muscle, thalamus, and colon. |
| Induction: | |
By p53/TP53 following DNA damage. {ECO:0000269|PubMed:12692263}. |
| Sequence caution: | |
Sequence=AAW30734.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.