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UniProt functional annotation for Q99257 | ||
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| UniProt code: Q99257. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in the export of mRNA from the nucleus to the cytoplasm. {ECO:0000255|PROSITE-ProRule:PRU00611, ECO:0000269|PubMed:9214641}. |
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| Subunit: | |
Interacts with nucleoporin complex NUP84 and MTR2. Interacts with MIP6. {ECO:0000269|PubMed:12835756, ECO:0000269|PubMed:9214641}. |
| Subcellular location: | |
Nucleus. Cytoplasm. Note=Localizes at both the nuclear and cytoplasmic site of the pores. Shuttles between the nucleus and the cytoplasm. |
| Domain: | |
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus. {ECO:0000250}. |
| Domain: | |
The NTF2 domain heterodimerizes with MTR2. The formation of this heterodimer is essential for mRNA export and binds to all of the nucleoporin-FG-repeats. |
| Domain: | |
The RNA-binding domain is conserved in most NXF proteins but may be absent in yeasts. |
| Miscellaneous: | |
Present with 2830 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the NXF family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.