UniProt functional annotation for Q00688

UniProt code: Q00688.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
 
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation: Inhibited preferentially by rapamycin over FK506.
Subcellular location: Nucleus.
Similarity: Belongs to the FKBP-type PPIase family.
Similarity: Contains 1 PPIase FKBP-type domain.
Sequence caution: Sequence=AAA58474.1; Type=Frameshift; Positions=197;

Annotations taken from UniProtKB at the EBI.