UniProt functional annotation for P63239

UniProt code: P63239.

Organism: Mus musculus (Mouse).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
 
Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
 
Catalytic activity: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys- Arg-|- bonds.
Cofactor: Calcium.
Biophysicochemical properties: pH dependence: Optimum pH is 5.5-6.5;
Subcellular location: Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Similarity: Belongs to the peptidase S8 family. Furin subfamily.

Annotations taken from UniProtKB at the EBI.