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UniProt functional annotation for Q9HB20 | ||
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| UniProt code: Q9HB20. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
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| Subunit: | |
Interacts with GTP-bound ARF1 (PubMed:15107860, PubMed:21454700). Interacts with SACM1L and VAPA and/or VAPB to form a ternary complex (PubMed:30659099). {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:21454700, ECO:0000269|PubMed:30659099}. |
| Subcellular location: | |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Localizes to ER-trans Golgi network (TGN) contacts sites. {ECO:0000269|PubMed:30659099}. |
| Tissue specificity: | |
Widely expressed. |
| Domain: | |
The PH domain binds the small GTPase ARF1 and phosphatidylinositol-4-phosphate (PtdIns4P) with high selectivity, and is required for its recruitment to the trans-Golgi network (TGN). {ECO:0000269|PubMed:15107860}. |
| Sequence caution: | |
Sequence=BAA90927.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.