PDBsum entry 2kaw

Signaling protein

PDB id

2kaw

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Contents

			Protein chain

					90 a.a. *

			Ligands

					SUZ

* Residue conservation analysis

PDB id:

2kaw

Links

Name:

Signaling protein

Title:

Nmr structure of the mdvl1 pdz domain in complex with its inhibitor

Structure:

Segment polarity protein dishevelled homolog dvl-1. Chain: a. Fragment: unp residues 248-337, pdz domain. Synonym: dishevelled-1, dsh homolog 1. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: dvl1, dvl. Expressed in: escherichia coli. Expression_system_taxid: 562.

NMR struc:

20 models

Authors:

H.J.Lee,Y.Shao,N.X.Wang,D.L.Shi,J.J.Zheng

Key ref:

H.J.Lee et al. (2009). Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. Angew Chem Int Ed Engl, 48, 6448-6452. PubMed id: 19637179

Date:

17-Nov-08

Release date:

15-Sep-09

PROCHECK

	Headers

	References

Protein chain

P51141 (DVL1_MOUSE) - Segment polarity protein dishevelled homolog DVL-1 from Mus musculus

Seq: Struc:

Seq: Struc:					695 a.a. 90 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Angew Chem Int Ed Engl 48:6448-6452 (2009)
PubMed id: 19637179

Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled.
H.J.Lee, N.X.Wang, D.L.Shi, J.J.Zheng.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

20509869

H.J.Lee, and J.J.Zheng (2010).
PDZ domains and their binding partners: structure, specificity, and modification.

Cell Commun Signal, 8, 8.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.