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UniProt functional annotation for P15891 | ||
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| UniProt code: P15891. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Regulates ARP2/3 complex-mediated actin assembly. Recruits ARP2/3 complex to sides of preexisting actin filaments, which may promote nucleation or stabilization of filament branches. Binds to actin filaments, but not actin monomers. Actin binding is required for ARP2/3 complex activation. May also have a role in linking the actin cytoskeleton to endocytosis. recruits components of the endocytotic machinery to cortical actin patches, known sites of endocytosis. {ECO:0000269|PubMed:11331312}. |
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| Subunit: | |
Binds F-actin, but not G-actin. Interacts with the ARP2/3 complex. Interacts with APP1, ARK1, PRK1, SCP1, SRV2 and YIR003W via its SH3 domain. Interacts with the SH3 domain of RVS167 and with SLA1. {ECO:0000269|PubMed:10388809, ECO:0000269|PubMed:11331312, ECO:0000269|PubMed:11668184, ECO:0000269|PubMed:11950888, ECO:0000269|PubMed:14737190, ECO:0000269|PubMed:8552082}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:11950888, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15872087}. Note=Cortical actin patches. |
| Ptm: | |
The actin depolymerizing factor homology (ADF) domain mediates actin filament binding. |
| Miscellaneous: | |
Present with 606 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the ABP1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.