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UniProt functional annotation for P68466 | ||
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| UniProt code: P68466. |
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| Organism: | |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)). |
| Taxonomy: | |
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus. |
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| Function: | |
Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation. |
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| Subunit: | |
Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation. {ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:19913487}. |
| Similarity: | |
Belongs to the poxviridae K7 protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.