UniProt functional annotation for Q9XYH7



	UniProt functional annotation for Q9XYH7

UniProt code: Q9XYH7.

Organism: Toxoplasma gondii.

Taxonomy: Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.

Function: Escorter protein required for import of MIC1 and MIC4 adhesins into the microneme. {ECO:0000269|PubMed:11157983, ECO:0000269|PubMed:16166092, ECO:0000269|PubMed:18818666}.

Subunit: Interacts directly with MIC1. Part of the MIC6-MIC1-MIC4 complex. {ECO:0000269|PubMed:11157983, ECO:0000269|PubMed:16166092, ECO:0000269|PubMed:18818666}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, microneme membrane {ECO:0000269|PubMed:11157983, ECO:0000269|PubMed:11861763, ECO:0000269|PubMed:18818666}; Single-pass type I membrane protein {ECO:0000269|PubMed:11157983, ECO:0000269|PubMed:11861763}. Secreted. Note=Released as soluble 35 kDa protein after proteolytic processing of the C-terminus (PubMed:11861763).

Developmental stage: Detected in tachyzoites (at protein level). Expressed in rapidly dividing tachyzoites. {ECO:0000269|PubMed:11861763}.

Domain: The EGF-like domains 2 and 3 and part of the acidic domain interact with the galectin-like domain of MIC1. The presence of at least one of the EGF-like domains, EGF-like domain 2 or EGF-like domain 3, is required for targeting of MIC1 and MIC4 into the microneme. {ECO:0000269|PubMed:16166092, ECO:0000269|PubMed:18818666}.

Ptm: Subject to proteolytic processing involving both the N-terminus and the C-terminus. The first EGF-like domain (EGF-like domain 1) is removed by proteolytic cleavage and is not present in the mature protein. Released as soluble 35 kDa protein after proteolytic processing at the C-terminus. {ECO:0000269|PubMed:11861763}.

Annotations taken from UniProtKB at the EBI.


Organism:		Toxoplasma gondii.
Taxonomy:		Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.



Function:		Escorter protein required for import of MIC1 and MIC4 adhesins into the microneme. {ECO:0000269\|PubMed:11157983, ECO:0000269\|PubMed:16166092, ECO:0000269\|PubMed:18818666}.


Subunit:		Interacts directly with MIC1. Part of the MIC6-MIC1-MIC4 complex. {ECO:0000269\|PubMed:11157983, ECO:0000269\|PubMed:16166092, ECO:0000269\|PubMed:18818666}.
Subcellular location:		Cytoplasmic vesicle, secretory vesicle, microneme membrane {ECO:0000269\|PubMed:11157983, ECO:0000269\|PubMed:11861763, ECO:0000269\|PubMed:18818666}; Single-pass type I membrane protein {ECO:0000269\|PubMed:11157983, ECO:0000269\|PubMed:11861763}. Secreted. Note=Released as soluble 35 kDa protein after proteolytic processing of the C-terminus (PubMed:11861763).
Developmental stage:		Detected in tachyzoites (at protein level). Expressed in rapidly dividing tachyzoites. {ECO:0000269\|PubMed:11861763}.
Domain:		The EGF-like domains 2 and 3 and part of the acidic domain interact with the galectin-like domain of MIC1. The presence of at least one of the EGF-like domains, EGF-like domain 2 or EGF-like domain 3, is required for targeting of MIC1 and MIC4 into the microneme. {ECO:0000269\|PubMed:16166092, ECO:0000269\|PubMed:18818666}.
Ptm:		Subject to proteolytic processing involving both the N-terminus and the C-terminus. The first EGF-like domain (EGF-like domain 1) is removed by proteolytic cleavage and is not present in the mature protein. Released as soluble 35 kDa protein after proteolytic processing at the C-terminus. {ECO:0000269\|PubMed:11861763}.