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PDBsum entry 2k1j
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Gene regulation
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PDB id
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2k1j
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References listed in PDB file
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Key reference
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Title
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Solution structure and nmr characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ing4.
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Authors
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A.Palacios,
P.Garcia,
D.Padró,
E.López-Hernández,
I.Martín,
F.J.Blanco.
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Ref.
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Febs Lett, 2006,
580,
6903-6908.
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PubMed id
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Abstract
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Plant homeodomain (PHD) fingers are frequently present in proteins involved in
chromatin remodelling, and some of them bind to histones. The family of proteins
inhibitors of growth (ING) contains a PHD finger that bind to histone-3
trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear
phosphoinositide receptors. We have determined the structure of ING4 PHD, and
characterised its binding to phosphoinositides and histone methylated tails. In
contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar
affinity to the different methylation states of histone-3 at lysine 4.
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