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UniProt functional annotation for Q5HZG4 | ||
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| UniProt code: Q5HZG4. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. {ECO:0000269|PubMed:17704303}. |
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| Subunit: | |
Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2 (By similarity). Interacts with TBPL2. {ECO:0000250, ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:17704303, ECO:0000269|PubMed:18682226}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:17704303}. |
| Domain: | |
The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3). |
| Similarity: | |
Belongs to the TAF3 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAH89030.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.