PDBsum entry 2jx8

Transcription

PDB id

2jx8

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Contents

			Protein chain

					47 a.a. *

* Residue conservation analysis

PDB id:

2jx8

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

Transcription

Title:

Solution structure of hpcif1 ww domain

Structure:

Phosphorylated ctd-interacting factor 1. Chain: a. Fragment: ww domain. Synonym: hpcif1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

NMR struc:

20 models

Authors:

T.Kouno,Y.Iwamoto,Y.Hirose,T.Aizawa,M.Demura,K.Kawano,Y.Ohkuma, M.Mizuguchi

Date:

09-Nov-07

Release date:

11-Nov-08

PROCHECK

	Headers

	References

Protein chain

Q9H4Z3 (PCIF1_HUMAN) - mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase from Homo sapiens

Seq: Struc:

Seq: Struc:					704 a.a. 47 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.1.1.62 - mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H⁺

5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA	+	S-adenosyl-L-methionine	=	5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA	+	S-adenosyl-L-homocysteine	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site