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UniProt functional annotation for P68425 | ||
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| UniProt code: P68425. |
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| Organism: | |
Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Haplopelma. |
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| Function: | |
Dual-function toxin that inhibits both serine proteases (trypsin) and voltage-gated potassium channels (Kv). The toxin is more active on Kv1.1/KCNA1 (78% inhibition), than on Kv1.2/KCNA2 (10% inhibition), and Kv1.3/KCNA3 (28% inhibition), although a high dose (5 uM) is needed. The inhibition of potassium channels is voltage- dependent. {ECO:0000269|PubMed:15066414, ECO:0000269|PubMed:16820861}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Mass spectrometry: | |
Mass=6166.23; Method=MALDI; Evidence={ECO:0000269|PubMed:15066414}; |
| Toxic dose: | |
LD(50) is 256 +/- 23 ug/kg by injection into the fourth ventricle of the adult mouse brain. {ECO:0000269|PubMed:15066414}. |
| Similarity: | |
Belongs to the venom Kunitz-type family. 02 (native) subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.