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UniProt functional annotation for Q08465 | ||
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| UniProt code: Q08465. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Histone-binding component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. YNG1 is required for the HAT activity of NuA3 but not for its integrity. Mediates the interaction of SAS3 with nucleosomes. {ECO:0000269|PubMed:12077334, ECO:0000269|PubMed:17157260}. |
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| Subunit: | |
Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6. Interacts with histone H3-K4 trimethylated. {ECO:0000269|PubMed:12077334, ECO:0000269|PubMed:16728974, ECO:0000269|PubMed:17157260}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:14562095}. |
| Domain: | |
The PHD-type zinc finger mediates the binding to H3K4me3. {ECO:0000269|PubMed:16728974}. |
| Miscellaneous: | |
Present with 861 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the ING family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.