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PDBsum entry 2jed
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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The crystal structure of the kinase domain of the protein kinasE C theta in complex with nvp-xaa228 at 2.32a resolution.
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Structure:
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Protein kinasE C theta. Chain: a, b. Fragment: kinase domain 361-706. Synonym: npkc-theta. Mutation: yes. Other_details: phosphoserine 676, phosphoserine 695, c540 modified
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Source:
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Homo sapiens. Human. Organism_taxid: 9606
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Resolution:
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2.32Å
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R-factor:
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0.188
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R-free:
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0.221
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Authors:
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W.Stark,F.Bitsch,A.Berner,F.Buelens,P.Graff,H.Depersin,M.Geiser, R.Knecht,J.Rahuel,G.Rummel,J.M.Schlaeppi,R.Schmitz,A.Strauss, J.Wagner
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Key ref:
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W.Stark
et al.
The crystal structure of the kinase domain of the protein kinase c theta in complex with nvp-Xaa228.
To be published,
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Date:
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16-Jan-07
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Release date:
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05-Feb-08
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PROCHECK
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Headers
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References
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Q04759
(KPCT_HUMAN) -
Protein kinase C theta type from Homo sapiens
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Seq:
Struc:
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706 a.a.
326 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.11.13
- protein kinase C.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
