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UniProt functional annotation for P30626 | ||
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| UniProt code: P30626. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}. |
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| Subunit: | |
Homodimer. Interacts with GCA, RYR2 and ANXA7. {ECO:0000269|PubMed:12804766, ECO:0000269|PubMed:17699613}. |
| Subcellular location: | |
Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. |
| Tissue specificity: | |
Detected in cardiac myocytes. |
| Miscellaneous: | |
This protein is encoded by an amplified gene in multidrug-resistant cells. |
| Miscellaneous: | |
This protein has been shown to bind calcium with high affinity. |
Annotations taken from UniProtKB at the EBI.