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UniProt functional annotation for Q5T5U3 | ||
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| UniProt code: Q5T5U3. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
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| Subunit: | |
Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169, ECO:0000269|PubMed:16527809, ECO:0000269|PubMed:17347647}. |
| Subcellular location: | |
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. |
| Tissue specificity: | |
Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. {ECO:0000269|PubMed:12056806}. |
| Induction: | |
Up-regulated upon cell differentiation. {ECO:0000269|PubMed:12056806}. |
| Ptm: | |
Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes. {ECO:0000269|PubMed:22922005}. |
| Miscellaneous: | |
Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers. |
| Miscellaneous: | |
Required for In1A-dependent entry of Listeria monocytogenes into cells. |
| Sequence caution: | |
Sequence=AAM22955.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.