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UniProt functional annotation for Q15485 | ||
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| UniProt code: Q15485. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:17215869}. |
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| Subunit: | |
Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2. Interacts with CR1. {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:23460739, ECO:0000269|PubMed:8586615}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the liver and secreted in plasma. |
| Domain: | |
The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding. {ECO:0000269|PubMed:17215869}. |
| Similarity: | |
Belongs to the ficolin lectin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.