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UniProt functional annotation for Q3UV74 | ||
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| UniProt code: Q3UV74. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response. {ECO:0000269|PubMed:16836649}. |
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| Subunit: | |
Monomer and homodimer (Probable). Unlike integrin beta chains, no alpha chain partner has yet been found. {ECO:0000269|PubMed:11461913, ECO:0000269|PubMed:17523188, ECO:0000305}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:11461913, ECO:0000269|PubMed:14662885, ECO:0000269|PubMed:9535848}; Single-pass type I membrane protein {ECO:0000269|PubMed:11461913, ECO:0000269|PubMed:14662885, ECO:0000269|PubMed:9535848}. Note=In unactivated neutrophils, the majority of the protein is contained in intracellular granules and is released to the cell surface following inflammatory activation or induction of necrotic or apoptotic cell death. {ECO:0000269|PubMed:11461913, ECO:0000269|PubMed:14662885, ECO:0000269|PubMed:9535848}. |
| Tissue specificity: | |
Expressed predominantly in maturing and mature neutrophils. {ECO:0000269|PubMed:11461913}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:11461913}. |
| Polymorphism: | |
Strain C57BL/6 preferentially expresses isoform 1 while strains BALB/c and C3H/HeJ preferentially express isoform 2. This is due to a single nucleotide difference at the second splice acceptor site in exon 13 which results in production of isoform 2 when this splice site is used in strains BALB/c and C3H/HeJ. {ECO:0000269|PubMed:11461913}. |
| Disruption phenotype: | |
Mice display normal neutrophil maturation and function including appropriate migration into sites of inflammation and response to bacterial infection. Following inflammatory stimulus in the peritoneal cavity, they display decreased levels of Cxcl13 due to the migration of resident Cxcl13-expressing macrophages from the peritoneal cavity during the inflammatory response. {ECO:0000269|PubMed:14662885, ECO:0000269|PubMed:16836649}. |
| Miscellaneous: | |
The human orthologous protein seems not to exist. |
| Similarity: | |
Belongs to the integrin beta chain family. {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.