UniProt functional annotation for P57766



	UniProt functional annotation for P57766

UniProt code: P57766.

Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus).

Taxonomy: Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus.

Function: One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. {ECO:0000269|PubMed:12535540, ECO:0000269|PubMed:17011573}.

Subunit: Forms heterodimers with PCNA2, which then recruit PCNA3; does not form homotrimers (PubMed:12535540, PubMed:18703842). The heterodimers interact with RfcS homotetramers (PubMed:12535540). Heterotrimer which circularizes head-to-tail (head is at N-terminus, tail is at C-terminus) to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA. Heterotrimer interacts, probably via this subunit, with flap endonuclease 1 (fen) (PubMed:12535540), Hjc (PubMed:17011573), Dpo4 (PubMed:19054331), and XPF (PubMed:12675797). {ECO:0000269|PubMed:12535540, ECO:0000269|PubMed:12675797, ECO:0000269|PubMed:16945955, ECO:0000269|PubMed:17011573, ECO:0000269|PubMed:17012780, ECO:0000269|PubMed:17052461, ECO:0000269|PubMed:18703842, ECO:0000269|PubMed:19054331}.

Similarity: Belongs to the PCNA family. {ECO:0000255|HAMAP- Rule:MF_00317}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus).
Taxonomy:		Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus.



Function:		One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation. {ECO:0000269\|PubMed:12535540, ECO:0000269\|PubMed:17011573}.


Subunit:		Forms heterodimers with PCNA2, which then recruit PCNA3; does not form homotrimers (PubMed:12535540, PubMed:18703842). The heterodimers interact with RfcS homotetramers (PubMed:12535540). Heterotrimer which circularizes head-to-tail (head is at N-terminus, tail is at C-terminus) to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA. Heterotrimer interacts, probably via this subunit, with flap endonuclease 1 (fen) (PubMed:12535540), Hjc (PubMed:17011573), Dpo4 (PubMed:19054331), and XPF (PubMed:12675797). {ECO:0000269\|PubMed:12535540, ECO:0000269\|PubMed:12675797, ECO:0000269\|PubMed:16945955, ECO:0000269\|PubMed:17011573, ECO:0000269\|PubMed:17012780, ECO:0000269\|PubMed:17052461, ECO:0000269\|PubMed:18703842, ECO:0000269\|PubMed:19054331}.
Similarity:		Belongs to the PCNA family. {ECO:0000255\|HAMAP- Rule:MF_00317}.