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UniProt functional annotation for O15492 | ||
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| UniProt code: O15492. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity). {ECO:0000250|UniProtKB:P97428, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:18434541}. |
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| Subunit: | |
Interacts with GNAI1 and GNAQ (PubMed:18434541). Interacts with GNAI2, GNAI3 and GNAO1 (By similarity). {ECO:0000250|UniProtKB:P97428, ECO:0000269|PubMed:18434541}. |
| Subcellular location: | |
Membrane {ECO:0000250|UniProtKB:P97428}; Lipid- anchor {ECO:0000250|UniProtKB:P97428}. |
| Tissue specificity: | |
Abundantly expressed in retina with lower levels of expression in most other tissues. |
| Ptm: | |
Palmitoylated on Cys-2 and/or Cys-12. {ECO:0000250|UniProtKB:P97428}. |
| Ptm: | |
Phosphorylated. Phosphorylation at Tyr-168 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1. {ECO:0000269|PubMed:11602604}. |
Annotations taken from UniProtKB at the EBI.