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PDBsum entry 2ijm
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protein ligands Protein-protein interface(s) links
Signaling protein,transferase PDB id
2ijm

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
260 a.a. *
Ligands
ATP
ADP
Waters ×184
* Residue conservation analysis
PDB id:
2ijm
Name: Signaling protein,transferase
Title: Crystal structure of focal adhesion kinase domain with 2 molecules in the asymmetric unit complexed with adp and atp
Structure: Focal adhesion kinase 1. Chain: a, b. Fragment: catalytic domain. Synonym: fadk 1. Pp125fak. Protein-tyrosine kinase 2. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.19Å     R-factor:   0.211     R-free:   0.271
Authors: C.C.Lee
Key ref: C.B.Andersen et al. Crystal structure of focal adhesion kinase catalytic domain complexed with ATP and novel 7h-Pyrrolo [2,3-D] pyrimidine inhibitor scaffolds. To be published, .
Date:
29-Sep-06     Release date:   14-Aug-07    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q05397  (FAK1_HUMAN) -  Focal adhesion kinase 1 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1052 a.a.
260 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.10.2  - non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
Bound ligand (Het Group name = ATP)
corresponds exactly 		+ ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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