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UniProt functional annotation for P27671 | ||
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| UniProt code: P27671. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:10373510}. |
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| Subunit: | |
Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability. {ECO:0000269|PubMed:10373510, ECO:0000269|PubMed:11500497}. |
| Tissue specificity: | |
Brain. |
| Domain: | |
The DH (DBL-homology) domain mediates interaction with RASGRF2. |
| Ptm: | |
Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. {ECO:0000250}. |
| Ptm: | |
Ubiquitinated and degraded following phosphorylation by PLK2. {ECO:0000305|PubMed:11500497}. |
| Ptm: | |
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity (By similarity). {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.