UniProt functional annotation for Q9LDC0

UniProt code: Q9LDC0.

Organism: Arabidopsis thaliana (Mouse-ear cress).
Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway. {ECO:0000250, ECO:0000269|PubMed:14517332, ECO:0000269|PubMed:14730066, ECO:0000269|PubMed:15133126, ECO:0000269|PubMed:16887800, ECO:0000269|PubMed:18499676, ECO:0000269|PubMed:20971896}.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit: Interacts with calmodulin (CaM), MRP1, MRP2, MDR1/PGP1, MDR11/PGP19 and SHD/HSP90. Interacts with 1-naphthylphthalamic acid (NPA). {ECO:0000269|PubMed:12410806, ECO:0000269|PubMed:14517332, ECO:0000269|PubMed:15133126, ECO:0000269|PubMed:18499676}.
Subcellular location: Cell membrane; Single-pass type IV membrane protein. Vacuole membrane; Single-pass type IV membrane protein. Endoplasmic reticulum.
Disruption phenotype: Plants display helical rotation of several organs. {ECO:0000269|PubMed:12410806}.
Similarity: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
Similarity: Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule:PRU00277}.
Similarity: Contains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.

Annotations taken from UniProtKB at the EBI.