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UniProt functional annotation for Q9VM64 | ||
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| UniProt code: Q9VM64. |
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| Organism: | |
Drosophila melanogaster (Fruit fly). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
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| Function: | |
Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc). {ECO:0000269|PubMed:16630821}. |
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| Subunit: | |
Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when facilitated by heparin, heparin is required to promote high-affinity interactions between hh and iHog. {ECO:0000269|PubMed:16630821, ECO:0000269|PubMed:17077139}. |
| Subcellular location: | |
Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255, ECO:0000269|PubMed:16630821}. |
| Developmental stage: | |
Expressed both maternally and zygotically. {ECO:0000269|PubMed:16630821}. |
| Domain: | |
The first Fibronectin type-III domain mediates a specific interaction with Hh protein, in vitro. The second Fibronectin type-III domain is additionally required for in vivo signaling activity. {ECO:0000269|PubMed:16630821}. |
| Disruption phenotype: | |
Patterning defects characteristic of Hh signaling loss in embryos and imaginal disks. {ECO:0000269|PubMed:16630821}. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. IHOG family. {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.