PDBsum entry 2i6l

Transferase

PDB id: 2i6l

Contents

Protein chains

292 a.a. *

269 a.a. *

Waters ×79

* Residue conservation analysis

Obsolete entry

PDB id:

2i6l

Name:

Transferase

Title:

Crystal structure of human mitogen activated protein kinase 6 (mapk6)

Structure:

Mitogen-activated protein kinase 6. Chain: a, b. Synonym: extracellular signal-regulated kinase 3, erk-3, map kinase isoform p97, p97- mapk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk6, erk3, prkm6. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.25Å R-factor: 0.224 R-free: 0.272

Authors:

P.Filippakopoulos,A.P.Turnbull,P.Savitsky,O.Fedorov,G.Berridge,S.Das, J.Elkins,M.Soundararajan,X.W.Yang,D.Doyle,E.Papagrigoriou, A.C.W.Pike,G.Bunkonczi,E.Ugochukwu,J.Debreczeni,F.Von Delft, A.Edwards,C.Arrowsmith,M.Sundstrom,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

P.Filippakopoulos et al. Crystal structure of the human mitogen activated protein kinase 6. To be published, .

Date:

29-Aug-06 Release date: 12-Sep-06

Protein chain

Q16659  (MK06_HUMAN) -  Mitogen-activated protein kinase 6 from Homo sapiens

Seq: 721 a.a.

Struc: 292 a.a.*

Protein chain

Q16659  (MK06_HUMAN) -  Mitogen-activated protein kinase 6 from Homo sapiens

Seq: 721 a.a.

Struc: 269 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site