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PDBsum entry 2i1p
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Ligand binding protein
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PDB id
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2i1p
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References listed in PDB file
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Key reference
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Title
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Solution structure of the twelfth cysteine-Rich ligand-Binding repeat in rat megalin.
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Authors
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C.A.Wolf,
F.Dancea,
M.Shi,
V.Bade-Noskova,
H.Rüterjans,
D.Kerjaschki,
C.Lücke.
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Ref.
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J Biomol Nmr, 2007,
37,
321-328.
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PubMed id
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Abstract
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Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand
transporter, is a member of the low density lipoprotein receptor gene family.
Several cysteine-rich repeats, each consisting of about 40 residues, are
responsible for the multispecific binding of ligands. The solution structure of
the twelfth cysteine-rich ligand-binding repeat with class A motif found in
megalin features two short beta-strands and two helical turns, yielding the
typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern
and a calcium coordination site at the C-terminal end. The resulting differences
in electrostatic surface potential compared to other ligand-binding modules of
this gene family, however, may be responsible for the functional divergence.
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