PDBsum entry 2hy8

Transferase

PDB id: 2hy8

Contents

Protein chain

293 a.a. *

Ligands

1ST

Waters ×192

* Residue conservation analysis

PDB id:

2hy8

Name:

Transferase

Title:

Pak1 complex with st2001

Structure:

Serine/threonine-protein kinase pak 1. Chain: 1. Fragment: kinase domain (residues 249-545). Synonym: p21-activated kinase 1, pak-1, p65-pak, alpha-pak. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pak1. Expressed in: escherichia coli. Expression_system_taxid: 562

Biol. unit:

Dimer (from PQS)

Resolution:

2.00Å R-factor: 0.208 R-free: 0.234

Authors:

U.Schulze-Gahmen,H.Lu

Key ref:

H.Lu et al. Crystal structure of the complex between human pak1-Kinase and 3-Hydroxystaurosporine. To be published, .

Date:

04-Aug-06 Release date: 07-Nov-06

Protein chain

Q13153  (PAK1_HUMAN) -  Serine/threonine-protein kinase PAK 1 from Homo sapiens

Seq: 545 a.a.

Struc: 293 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site