UniProt functional annotation for P23467

UniProt code: P23467.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity). {ECO:0000250}.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
Subunit: Monomer. Interacts with TEK. Interacts via fibronectin type-III 17 domain with CDH5 (By similarity). {ECO:0000250}.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Induction: Up-regulated by hypoxia. {ECO:0000269|PubMed:19116766}.
Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. {ECO:0000305}.
Similarity: Contains 17 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Similarity: Contains 1 tyrosine-protein phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00160}.

Annotations taken from UniProtKB at the EBI.